The Scientific Collaboration Framework (SCF) is reusable software that can be used to develop web-based, collaborative, scientific communities. The framework is designed to support interdisciplinary scientists in publishing, annotating, sharing and discussing content such as articles, perspectives, interviews and news items, as well as assert personal biographies and research interests – the basics of any online community. These web materials can then be linked to external, heterogeneous knowledge repositories of life science resources such as genes, antibodies, cell-lines or model organisms. SCF, thus supports structured “Web 2.0” style community discourse amongst researchers, makes various data resources available to the collaborating scientist and captures the semantics of the relationship among the discourse and resources.